Hyposmia and executive dysfunction as predictors of future Parkinson's disease: A prospective study
- 15 May 2009
- journal article
- research article
- Published by Wiley in Movement Disorders
- Vol. 24 (7), 1060-1065
- https://doi.org/10.1002/mds.22534
Abstract
Olfactory deficits and executive dysfunction are early and common symptoms in Parkinson's disease (PD). Previous studies have shown that hyposmia can be a first sign of PD. The aim of the present study was to determine which of three olfactory tests and two selected tests of executive function would be the best predictor of future PD over a 5 year period. In a cohort of 361 nonparkinsonian, nondemented first-degree relatives of PD patients, in whom alternative causes of olfactory dysfunction were excluded, we measured baseline performance on three olfactory and two executive function tasks. Five years from baseline, clinical neurological evaluation and/or a screening questionnaire, sensitive to the presence of Parkinsonism, were used to detect individuals developing clinical PD. Our results show that in first degree relatives of PD patients worse performance on each of three olfactory processing tasks was associated with an increased risk of developing PD within 5 years, whereas performance on selected tests of executive dysfunction was not associated with an increased risk of developing PD. Interestingly, impaired odor discrimination was the best predictor for future PD. © 2009 Movement Disorder SocietyKeywords
This publication has 28 references indexed in Scilit:
- Association of olfactory dysfunction with risk for future Parkinson's diseaseAnnals of Neurology, 2008
- Different Odor Tests Contribute Differently to the Evaluation of Olfactory LossChemical Senses, 2007
- Olfactory loss may be a first sign of idiopathic Parkinson's diseaseMovement Disorders, 2007
- Idiopathic hyposmia as a preclinical sign of Parkinson's diseaseAnnals of Neurology, 2004
- Detection of presymptomatic Parkinson's disease: Combining smell tests, transcranial sonography, and SPECTMovement Disorders, 2004
- The cognitive ability of an incident cohort of Parkinson’s patients in the UK. The CamPaIGN studyBrain, 2004
- Olfactory dysfunction in Parkinson's disease.Journal of Neurology, Neurosurgery & Psychiatry, 1997
- Cognitive deficits precede motor deficits in a slowly progressing model of parkinsonism in the monkeyNeurodegeneration, 1995
- Bilateral olfactory dysfunction in early stage treated and untreated idiopathic Parkinson's disease.Journal of Neurology, Neurosurgery & Psychiatry, 1992
- Cognitive function in Parkinson's disease: From description to theoryTrends in Neurosciences, 1990