Circulating MicroRNAs
- 3 February 2012
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation Research
- Vol. 110 (3), 483-495
- https://doi.org/10.1161/circresaha.111.247452
Abstract
In the past few years, the crucial role of different micro-RNAs (miRNAs) in the cardiovascular system has been widely recognized. Recently, it was discovered that extracellular miRNAs circulate in the bloodstream and that such circulating miRNAs are remarkably stable. This has raised the possibility that miRNAs may be probed in the circulation and can serve as novel diagnostic markers. Although the precise cellular release mechanisms of miRNAs remain largely unknown, the first studies revealed that these circulating miRNAs may be delivered to recipient cells, where they can regulate translation of target genes. In this review, we will discuss the nature of the stability of miRNAs that circulate in the bloodstream and discuss the available evidence regarding the possible function of these circulating miRNAs in distant cell-to-cell communication. Furthermore, we summarize and discuss the usefulness of circulating miRNAs as biomarkers for a wide range of cardiovascular diseases such as myocardial infarction, heart failure, atherosclerosis, hypertension, and type 2 diabetes mellitus.Keywords
This publication has 68 references indexed in Scilit:
- MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteinsNature, 2011
- Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasmaProceedings of the National Academy of Sciences of the United States of America, 2011
- Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell MigrationMolecular Cell, 2010
- Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular ProtectionScience Signaling, 2009
- Toward MicroRNA–Based Therapeutics for Heart DiseaseCirculation Research, 2008
- Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseasesCell Research, 2008
- Circulating microRNAs as stable blood-based markers for cancer detectionProceedings of the National Academy of Sciences of the United States of America, 2008
- Detection of elevated levels of tumour‐associated microRNAs in serum of patients with diffuse large B‐cell lymphomaBritish Journal of Haematology, 2008
- Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cellsNature, 2007
- The functions of animal microRNAsNature, 2004