The Association of Telomere Length and Cancer: a Meta-analysis
Top Cited Papers
- 1 June 2011
- journal article
- research article
- Published by American Association for Cancer Research (AACR) in Cancer Epidemiology, Biomarkers & Prevention
- Vol. 20 (6), 1238-1250
- https://doi.org/10.1158/1055-9965.epi-11-0005
Abstract
Background: Telomeres shorten with each cell division and are essential for chromosomal stability. Short telomeres in surrogate tissues (e.g., blood cells) are associated with increased cancer risk in several case–control studies, but findings are inconsistent in prospective studies. Methods: We systematically reviewed studies published prior to August 30, 2010, on the association between telomere length (TL) in surrogate tissues and cancer. There were 27 reports on 13 cancers and/or incident cancer investigating this association. The majority, 16, were retrospective case–control studies, 11 were prospective studies. Meta-analyses were conducted to determine ORs and 95% CIs for these studies. Results: Studies on bladder, esophageal, gastric, head and neck, ovarian, renal, and overall incident cancer found associations between short telomeres and these cancers. Non–Hodgkin lymphoma, breast, lung, and colorectal cancer reports were inconsistent. Single studies on endometrial, prostate, and skin cancers were null. In a random-effects meta-analysis, short TL was significantly associated with cancer in retrospective studies (pooled OR for the shortest TL quartile compared with the longest: 2.9, 95% CI: 1.75–4.8, P < 0.0001). The pooled OR for prospective studies was 1.16 (95% CI: 0.87–1.54, P = 0.32). All studies combined yielded a pooled OR of 1.96 (95% CI: 1.37–2.81, P = 0.0001) for the association of short TL and cancer. Conclusion and Impact: There is suggestive evidence that short surrogate tissue TL is associated with cancer; the strongest evidence exists for bladder, esophageal, gastric, and renal cancers. Additional prospective studies with consistent methodology are needed to confirm this hypothesis. Cancer Epidemiol Biomarkers Prev; 20(6); 1238–50. ©2011 AACR.Keywords
This publication has 63 references indexed in Scilit:
- Telomere length and genetic analyses in population‐based studies of endometrial cancer riskCancer, 2010
- Genetic variation in telomere maintenance genes, telomere length, and lung cancer susceptibilityLung Cancer, 2009
- Leukocyte telomere length in a population-based case–control study of ovarian cancer: a pilot studyCancer Causes & Control, 2009
- The association between leukocyte telomere length and cigarette smoking, dietary and physical variables, and risk of prostate cancerAging Cell, 2009
- Chromosome 9 arm-specific telomere length and breast cancer riskCarcinogenesis: Integrative Cancer Research, 2009
- A Prospective Study of Telomere Length and the Risk of Skin CancerJournal of Investigative Dermatology, 2009
- Telomere length, oxidative damage, antioxidants and breast cancer riskInternational Journal of Cancer, 2009
- Telomere length measurement by a novel monochrome multiplex quantitative PCR methodNucleic Acids Research, 2009
- Telomere length shortening in non-Hodgkin's lymphoma patients undergoing chemotherapyAnnals of Hematology, 2003
- Meta-analysis in clinical trialsControlled Clinical Trials, 1986