Cytolytic molecules in rejection
- 1 February 2009
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Current Opinion in Organ Transplantation
- Vol. 14 (1), 30-33
- https://doi.org/10.1097/mot.0b013e32831c8462
Abstract
Acute and chronic rejection are major problems in clinical transplantation. Rejection is largely mediated by natural killer (NK) and T cells that use cytolytic molecules, including perforin, granzymes, granulysin, and Fas ligand, to eliminate the allograft. The purpose of this review is to inform the reader of recent advances in our understanding of the roles of cytolytic molecules in rejection and their potential as biomarkers of rejection.Although it is well accepted that T cells are the major effector cells in acute rejection, there is an increasing recognition that cells of the innate immune system, and in particular NK cells, also play a major role in allograft rejection.Both NK cells and cytotoxic T cells contribute to acute rejection. The major molecules involved include perforin, granzymes, granulysin, and Fas ligand. Molecular profiles that include these and other molecules may allow better management of organ allograft recipients.Keywords
This publication has 50 references indexed in Scilit:
- The Innate NK Cells, Allograft Rejection, and a Key Role for IL-15The Journal of Immunology, 2008
- The Innate Immune System in Allograft Rejection and ToleranceThe Journal of Immunology, 2007
- Do NK-cell receptors and alloreactivity affect solid organ transplantation?Transplant Immunology, 2006
- Analysis of the Innate and Adaptive Phases of Allograft Rejection by Cluster Analysis of Transcriptional ProfilesThe Journal of Immunology, 2002
- Pathways of allorecognition: implications for transplantation toleranceTransplant Immunology, 2002
- Multiple pathways to allograft rejectionTransplantation, 2002
- How to recongnize a foreign submarineImmunological Reviews, 1997
- MEDIATION OF SKIN ALLOGRAFT REJECTION IN scid MICE BY CD4+ AND CD8+ T CELLSTransplantation, 1992
- Migration of dendritic leukocytes from cardiac allografts into host spleens. A novel pathway for initiation of rejection.The Journal of Experimental Medicine, 1990
- LACK OF EVIDENCE FOR AN ACTIVE ROLE FOR NATURAL KILLER CELLS IN ACUTE REJECTION OF ORGAN ALLOGRAFTSTransplantation, 1985