Posttranscriptional Regulation of Insulin Family Ligands and Receptors
Open Access
- 18 September 2013
- journal article
- review article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 14 (9), 19202-19229
- https://doi.org/10.3390/ijms140919202
Abstract
Insulin system including ligands (insulin and IGFs) and their shared receptors (IR and IGFR) are critical regulators of insulin signaling and glucose homeostasis. Altered insulin system is associated with major pathological conditions like diabetes and cancer. The mRNAs encoding for these ligands and their receptors are posttranscriptionally controlled by three major groups of regulators; (i) alternative splicing regulatory factors; (ii) turnover and translation regulator RNA-binding proteins (TTR-RBPs); and (iii) non-coding RNAs including miRNAs and long non-coding RNAs (lncRNAs). In this review, we discuss the influence of these regulators on alternative splicing, mRNA stability and translation. Due to the pathological impacts of insulin system, we also discussed the possibilities of discovering new potential regulators which will improve understanding of insulin system and associated diseases.This publication has 134 references indexed in Scilit:
- LincRNA-p21 Suppresses Target mRNA TranslationMolecular Cell, 2012
- The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1rNature, 2012
- RNA-Binding Protein HuD Controls Insulin TranslationMolecular Cell, 2012
- The Lin28/let-7 Axis Regulates Glucose MetabolismCell, 2011
- Integrative Regulatory Mapping Indicates that the RNA-Binding Protein HuR Couples Pre-mRNA Processing and mRNA StabilityMolecular Cell, 2011
- The Spliceosome: Design Principles of a Dynamic RNP MachineCell, 2009
- MicroRNAs: Target Recognition and Regulatory FunctionsCell, 2009
- Diverse molecular functions of Hu proteinsCellular and Molecular Life Sciences, 2008
- Alterations in RNA‐binding activities of IRES‐regulatory proteins as a mechanism for physiological variability and pathological dysregulation of IGF‐IR translational control in human breast tumor cellsJournal of Cellular Physiology, 2008
- Phosphorylation of HuR by Chk2 Regulates SIRT1 ExpressionMolecular Cell, 2007