Plasma enterolactone and risk of colon and rectal cancer in a case–cohort study of Danish men and women
- 21 October 2009
- journal article
- research article
- Published by Springer Science and Business Media LLC in Cancer Causes & Control
- Vol. 21 (1), 153-162
- https://doi.org/10.1007/s10552-009-9445-5
Abstract
This case–cohort study examined the association between plasma enterolactone concentration and incidence of colon and rectal cancer in the Diet, Cancer and Health cohort, which enrolled 57,053 participants aged 50–64. Information about diet and lifestyle was obtained by questionnaire, and data on prescriptions of antibiotics were obtained from the Danish Prescription Registry. Cases diagnosed during 5.9 years of follow-up and a randomly selected sample of the cohort had a plasma sample analyzed for enterolactone by time-resolved fluoro-immuno assay. Associations were analyzed by Cox proportional hazards model. A total of 244 colon cancer cases, 137 rectal cancer cases, and 370 sub-cohort members were included in the statistical analyses. For each doubling in enterolactone concentration, we found lower risk of colon cancer among women [IRR (95% CI) = 0.76 (0.60–0.96)] and a tendency toward lower risk of rectal cancer [IRR (95% CI) = 0.83 (0.60–1.14)]. Among men, a doubling in enterolactone tended to be associated with higher risk of colon cancer [IRR (95% CI) = 1.09 (0.89–1.34)] and was associated with statistically significantly higher risk of rectal cancer [IRR (95% CI) = 1.74 (1.25–2.44)]. Exclusion of antibiotics users strengthened the results slightly. In conclusion, with higher enterolactone levels, we found lower risk of colon cancer among women and higher risk of rectal cancer among men.Keywords
This publication has 54 references indexed in Scilit:
- Structural determinants of plant lignans for the formation of enterolactone in vivoJournal of Chromatography B, 2002
- Phyto-oestrogens and cancerThe Lancet Oncology, 2002
- Use of Oral Antimicrobials Decreases Serum Enterolactone ConcentrationAmerican Journal of Epidemiology, 2002
- Interindividual Variation in Metabolism of Soy Isoflavones and Lignans: Influence of Habitual Diet on Equol Production by the Gut MicrofloraNutrition and Cancer, 2000
- Human metabolism of mammalian lignan precursors in raw and processed flaxseedThe American Journal of Clinical Nutrition, 1999
- 11 Phytoestrogen content in foodsBailliere's Clinical Endocrinology and Metabolism, 1998
- Naturally occurring oestrogens in foodPure and Applied Chemistry, 1998
- The excretion of lignans in rats — evidence for an intestinal bacterial source for this new group of compoundsFEBS Letters, 1981
- Lignans in man and in animal speciesNature, 1980
- Excretion, isolation and structure of a new phenolic constituent of female urineNature, 1980