Transcriptional Control Signals of a Eukaryotic Protein-Coding Gene
- 23 July 1982
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 217 (4557), 316-324
- https://doi.org/10.1126/science.6283634
Abstract
Transcriptional control signals of a model eukaryotic protein-coding gene have been identified by a new procedure of in vitro mutagenesis. This method allows small clusters of nucleotide residues to be substituted in a site-directed manner without causing the addition or deletion of other sequences. Transcription assays of a systematic series of these clustered point mutants have led to the identification of three distinct control signals located within the 105-nucleotide residues immediately upstream from the point where transcription begins.Keywords
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