Progressive−Convergent Elucidation of Stereochemistry in Complex Polyols. The Absolute Configuration of (−)-Sagittamide A
- 18 August 2006
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 128 (36), 11764-11765
- https://doi.org/10.1021/ja063735y
Abstract
The absolute stereostructure of sagittamide A (1), a O-hexacetyl long-chain hexahydroxy-α,ω-dicarboxylic acid, was assigned using a progressive−convergent approach that integrates three powerful regimens for stereochemical analysis of acyclic natural products: J-based analysis, 13C NMR universal database comparisons, and exciton coupling circular dichroism.Keywords
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