Emerging views of the nucleus as a cellular mechanosensor
- 1 April 2018
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 20 (4), 373-381
- https://doi.org/10.1038/s41556-018-0038-y
Abstract
The ability of cells to respond to mechanical forces is critical for numerous biological processes. Emerging evidence indicates that external mechanical forces trigger changes in nuclear envelope structure and composition, chromatin organization and gene expression. However, it remains unclear if these processes originate in the nucleus or are downstream of cytoplasmic signals. Here we discuss recent findings that support a direct role of the nucleus in cellular mechanosensing and highlight novel tools to study nuclear mechanotransduction.This publication has 164 references indexed in Scilit:
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