Regulated nucleosome mobility and the histone code
- 2 November 2004
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Structural & Molecular Biology
- Vol. 11 (11), 1037-1043
- https://doi.org/10.1038/nsmb851
Abstract
Post-translational modifications of the histone tails are correlated with distinct chromatin states that regulate access to DNA. Recent proteomic analyses have revealed several new modifications in the globular nucleosome core, many of which lie at the histone-DNA interface. We interpret these modifications in light of previously published data and propose a new and testable model for how cells implement the histone code by modulating nucleosome dynamics.Keywords
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