The importance of donor characteristics, post‐mortem time and preservation time for use and efficacy of donated corneas for posterior lamellar keratoplasty
- 25 June 2021
- journal article
- research article
- Published by Wiley in Acta Ophthalmologica
- Vol. 100 (3), 269-276
- https://doi.org/10.1111/aos.14943
Abstract
Purpose The aim of this study is to examine whether donor age, death-to-retrieval time (DRT) and death-to-preservation time (DPT) as well as total preservation time affect donor cornea suitability for endothelial keratoplasty (EK) or penetrating keratoplasty (PK). Methods A registry-based study was performed identifying 3248 corneas donated between 2011 and 2017. Data regarding donated corneas were extracted from The Danish Cornea Bank and donor medical records and evaluated for missing information. The primary outcome was whether ECD at preservation (ECD-P) or at release (ECD-R) was >2000 cells/mm2. Results Logistic regression for ECD-P showed a significant negative effect of increasing age (OR: 1.07, 95%CI: 1.05;1.08, p < 0.001) on donor suitability. Higher ECD-P had a significant positive effect on graft eligibility (OR: 1.007 95%CI: 1.003;1.010, p < 0.001). No significant effect of donor sex (p = 0.547), DRT (p = 0.289) or DPT (p = 0.102) on donor suitability for EK or PK (Chi-squared test). Conclusion High donor age and low ECD-P negatively affect the suitability of donor corneas for EK/PK whereas DRT and DPT did not affect graft suitability.Funding Information
- Aarhus Universitets Forskningsfond
This publication has 22 references indexed in Scilit:
- The Suitability of Corneas Stored by Organ Culture for Penetrating Keratoplasty and Influence of Donor and Recipient Factors on 5-Year Graft SurvivalInvestigative Ophthalmology & Visual Science, 2014
- The Effect of Donor Age on Penetrating Keratoplasty for Endothelial DiseaseOphthalmology, 2013
- Descemet's Stripping Endothelial KeratoplastyOphthalmology, 2011
- Endothelial Keratoplasty: The Relationship between Donor Tissue Storage Time and Donor Endothelial SurvivalOphthalmology, 2011
- Influencing factors on the suitability of organ-cultured corneasEye, 2010
- Corneal Grafting and BankingGlaucoma Surgery, 2009
- Donor Age and Corneal Endothelial Cell Loss 5 Years after Successful Corneal Transplantation: Specular Microscopy Ancillary Study ResultsOphthalmology, 2008
- Eye bank issues: II. Preservation techniques: warm versus cold storageInternational Ophthalmology, 2007
- Baseline Donor Characteristics in the Cornea Donor StudyCornea, 2005
- Corneal Grafting of Donor Tissue Preserved for Longer than 4 Weeks in Organ-Culture MediumCornea, 1995