Quantitative photoacoustic tomography with multiple optical sources
- 17 June 2010
- journal article
- Published by Optica Publishing Group in Applied Optics
- Vol. 49 (18), 3566-3572
- https://doi.org/10.1364/ao.49.003566
Abstract
Quantitative imaging of optical properties of biological tissues with high resolution has been a long-sought-after goal of many research groups. Photoacoustic imaging is a hybrid bio-optical imaging technique offering optical absorption contrast with ultrasonic spatial resolution. While photoacoustic methods offer significant promise for high-resolution optical imaging, quantification has thus far proved challenging. In this paper, a noniterative reconstruction technique for producing quantitative photoacoustic images of absorption perturbations is introduced for the case when the optical properties of the turbid background are known and when multiple optical illumination locations are used. Through theoretical developments and computational examples it is demonstrated that multiple-optical-source photoacoustic imaging can produce quantitative optical absorption reconstructions. The combination of optical and photoacoustic measurements is shown to yield improved reconstruction stability.Keywords
This publication has 15 references indexed in Scilit:
- Performance of iterative optoacoustic tomography with experimental dataApplied Physics Letters, 2009
- Estimating chromophore distributions from multiwavelength photoacoustic imagesJournal of the Optical Society of America A, 2009
- Quantitative photoacoustic tomography from boundary pressure measurements: noniterative recovery of optical absorption coefficient from the reconstructed absorbed energy mapJournal of the Optical Society of America A, 2008
- Tomographic imaging of absolute optical absorption coefficient in turbid media using combined photoacoustic and diffusing light measurementsOptics Letters, 2007
- Reconstruction of optical absorption coefficient maps of heterogeneous media by photoacoustic tomography coupled with diffusion equation based regularized Newton methodOptics Express, 2007
- Two-dimensional quantitative photoacoustic image reconstruction of absorption distributions in scattering media by use of a simple iterative methodApplied Optics, 2006
- Quantitative point source photoacoustic inversion formulas for scattering and absorbing mediaPhysical Review E, 2005
- Pulsed optoacoustic characterization of layered mediaJournal of Applied Physics, 2000
- Measurement of tissue optical properties by time-resolved detection of laser-induced transient stressApplied Optics, 1997
- Time-resolved laser optoacoustic tomography of inhomogeneous mediaApplied Physics B Laser and Optics, 1996