The human LASP1 gene is fused to MLL in an acute myeloid leukemia with t(11;17)(q23;q21)
- 9 January 2003
- journal article
- oncogenomics
- Published by Springer Science and Business Media LLC in Oncogene
- Vol. 22 (1), 157-160
- https://doi.org/10.1038/sj.onc.1206042
Abstract
The MLL gene at chromosome 11q23 is frequently rearranged in acute leukemia. Here we report the identification of a new MLL fusion partner in the case of an infant with AML-M4 and a t(11;17)(q23;q21) translocation. Fluorescence in situ hybridization (FISH) and RT-PCR analyses indicated a rearrangement of the MLL gene, but no fusion with previously identified MLL fusion partners at 17q, such as AF17 or MSF. Rapid amplification of cDNA ends (RACE) revealed an in-frame fusion of MLL to LASP1, a gene that is amplified and overexpressed in breast cancer. Retroviral transduction of myeloid progenitors demonstrated that MLL/LASP1 is the fourth known fusion of MLL with a cytoplasmic protein that has no in vitro transformation capability, thus establishing a potential subgroup among the MLL fusion proteins.Keywords
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