3-M syndrome: description of six new patients with review of the literature
- 1 October 2001
- journal article
- case report
- Published by Ovid Technologies (Wolters Kluwer Health) in Clinical Dysmorphology
- Vol. 10 (4), 241-252
- https://doi.org/10.1097/00019605-200110000-00002
Abstract
3-M syndrome combines pre- and postnatal growth retardation and dysmorphic facial features with autosomal recessive inheritance. Six new patients with 3-M syndrome are described and compared with 28 cases from the literature. Our six patients have a growth pattern, which parallels that of Silver-Russell syndrome (SRS). Final height is 1SD less in 3-M syndrome than in SRS. Growth hormone treatment significantly increased final height in two of our patients. 3-M syndrome can be differentiated from other types of dwarfism by clinical criteria and by the demonstration of characteristically slender long bones and foreshortened vertebral bodies. We propose that calculating the metacarpal and vertebral indices can be used to measure and document this important diagnostic feature. While the gonadal status of female patients with 3-M syndrome is completely normal, male patients have a gonadal dysfunction and sub- or infertility.Keywords
This publication has 17 references indexed in Scilit:
- 3-M syndrome and intracerebral aneurysms.Journal of Medical Genetics, 1994
- Three‐generation dominant transmission of the Silver‐Russell syndromeAmerican Journal of Medical Genetics, 1990
- 3M dwarfism: a study of two further sibs.Journal of Medical Genetics, 1989
- 3-M syndromeAmerican Journal of Medical Genetics, 1989
- Comment by Raoul C. M. Hennekam on the letter to the editor by FlanneryAmerican Journal of Medical Genetics, 1989
- Further delineation of the 3‐M syndrome with review of the literatureAmerican Journal of Medical Genetics, 1987
- 3-M Slender-Boned NanismAmerican Journal of Diseases of Children, 1981
- NORMAL VALUES OF THE VERTEBRAL BODY AND INTERVERTEBRAL DISK INDEX IN ADULTSAmerican Journal of Roentgenology, 1972
- NORMAL VALUES OF THE VERTEBRAL BODY AND INTERVERTEBRAL DISK INDEX DURING GROWTHAmerican Journal of Roentgenology, 1970
- Tables for predicting adult height from skeletal age: Revised for use with the greulich-pyle hand standardsThe Journal of Pediatrics, 1952