Nuclear size in carcinoma of the cervix: Its relation to DNA content and to prognosis
- 1 November 1964
- Vol. 17 (11), 1391-1399
- https://doi.org/10.1002/1097-0142(196411)17:11<1391::aid-cncr2820171106>3.0.co;2-f
Abstract
A method for estimating the nuclear size of squamous-cell carcinomas of the cervix is described. There was agreement between the nuclear size and DNA content (the latter being classified as near diploid or near tetraploid) in 159 cases (85%). There were, in fact, significantly more small-nucleus than large-nucleus tumors among patients with stage 1 conditions, whereas large-nucleus tumors preponderated in stages 3 and 4. A relation between the degree of differentiation and prognosis has also been found on the basis of a group of 385 tumors, but this relation is independent of the relation between nuclear size and prognosis.Keywords
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