Selenium and asthma: a complex relationship
- 28 June 2008
- Vol. 63 (7), 854-856
- https://doi.org/10.1111/j.1398-9995.2008.01676.x
Abstract
Descriptive studies in humans investigating the relationship between selenium (Se) status and asthma have presented inconsistent results. The concept of low Se status as a potential risk factor for increased prevalence or severity of asthma is based on the role that Se, through its incorporation into selenoproteins, plays as a potent antioxidant capable of augmenting the oxidative stress that accompanies asthma. However, Se intake also exerts a significant influence over immune responses. Thus, the dual effects of Se status on controlling oxidative stress in the lungs and regulating T helper 2 responses that drive allergic asthma, as well as which selenoproteins are key to regulating these processes, must be considered when attempting to decipher the relationship between this essential nutrient and complex allergic diseases such as asthma.Keywords
This publication has 17 references indexed in Scilit:
- A case‐control study of the relation between plasma selenium and asthma in European populations: a GA2LEN project*Allergy, 2008
- Selenoprotein H Is a Redox-sensing High Mobility Group Family DNA-binding Protein That Up-regulates Genes Involved in Glutathione Synthesis and Phase II DetoxificationJournal of Biological Chemistry, 2007
- Atopy, wheeze and bronchial responsiveness in young chilean adults. Do dietary antioxidants matter?Allergy, 2007
- Human selenoproteins at a glanceCellular and Molecular Life Sciences, 2005
- Relationship of Serum Antioxidants to Asthma Prevalence in YouthAmerican Journal of Respiratory and Critical Care Medicine, 2004
- Characterization of Mammalian SelenoproteomesScience, 2003
- A Comparative Study on the Hydroperoxide and Thiol Specificity of the Glutathione Peroxidase Family and Selenoprotein PJournal of Biological Chemistry, 2002
- Dietary Antioxidants and Asthma in AdultsAmerican Journal of Respiratory and Critical Care Medicine, 2001
- Bronchial reactivity and dietary antioxidantsThorax, 1997
- Lowered platelet glutathione peroxidase activity in patients with intrinsic asthmaAllergy, 1990