PEGylated Nanoceria as Radical Scavenger with Tunable Redox Chemistry
- 21 September 2009
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 131 (40), 14144-14145
- https://doi.org/10.1021/ja9051087
Abstract
We report the direct synthesis of cerium oxide nanoparticles (CNPs) in polyethylene glycol (PEG) based solutions with efficient radical scavenging properties. Synthesis of CNPs in PEG demonstrated a concentration dependent (of PEG) redox activity characterized by UV−visible spectroscopy. PEGylated CNPs acted as efficient radical scavengers, and superoxide dismutase (SOD) activity of CNPs synthesized in various concentration of PEG did not reduce compared to bare nanoceria. In addition to superoxide, PEGylated nanoceria demonstrated quenching of peroxide radicals as well. It was observed that the reaction with hydrogen peroxide leads to the formation of a charge transfer complex governed by the concentration of PEG. The stability of the charge transfer complex provides the tunable oxidation state of CNPs. The stability of this complex influences the regenerative capacity of the active 3+ oxidation state of CNPs. The cell viability as well as SOD activity of PEGylated CNPs is compared to those of bare CNPs, and the differences are outlined.Keywords
This publication has 23 references indexed in Scilit:
- Oxidase‐Like Activity of Polymer‐Coated Cerium Oxide NanoparticlesAngewandte Chemie-International Edition, 2009
- Synthesis of Biocompatible Dextran‐Coated Nanoceria with pH‐Dependent Antioxidant PropertiesSmall, 2008
- The role of cerium redox state in the SOD mimetic activity of nanoceriaBiomaterials, 2008
- Novel Synthesis of Cerium Oxide Nanoparticles for Free Radical ScavengingNanomedicine, 2007
- Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neuronsBiomaterials, 2007
- Cardioprotective effects of cerium oxide nanoparticles in a transgenic murine model of cardiomyopathyCardiovascular Research, 2007
- Superoxide dismutase mimetic properties exhibited by vacancy engineered ceria nanoparticlesChemical Communications, 2007
- Radical NanomedicineNanomedicine, 2006
- Rare earth nanoparticles prevent retinal degeneration induced by intracellular peroxidesNature Nanotechnology, 2006
- Vacancy Engineered Ceria Nanostructures for Protection from Radiation-Induced Cellular DamageNano Letters, 2005