A stabilized demethoxyviridin derivative inhibits PI3 kinase
- 1 August 2009
- journal article
- research article
- Published by Elsevier BV in Bioorganic & Medicinal Chemistry Letters
- Vol. 19 (15), 4223-4227
- https://doi.org/10.1016/j.bmcl.2009.05.105
Abstract
No abstract availableKeywords
This publication has 13 references indexed in Scilit:
- Abrogation of antibody-induced arthritis in mice by a self-activating viridin prodrug and association with impaired neutrophil and endothelial cell functionArthritis & Rheumatism, 2009
- Slow Self-Activation Enhances The Potency of Viridin ProdrugsJournal of Medicinal Chemistry, 2008
- Covalent Reactions of Wortmannin under Physiological ConditionsCell Chemical Biology, 2007
- Synthesis of fluorescent derivatives of wortmannin and demethoxyviridin as probes for phosphatidylinositol 3-kinaseBioorganic & Medicinal Chemistry Letters, 2006
- Wortmannin-C20 Conjugates Generate WortmanninJournal of Medicinal Chemistry, 2005
- Chemistry and biology of wortmanninOrganic & Biomolecular Chemistry, 2005
- Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signalingMolecular Cancer Therapeutics, 2004
- Synthesis and biological evaluation of synthetic viridins derived from C(20)-heteroalkylation of the steroidal PI-3-kinase inhibitor wortmanninOrganic & Biomolecular Chemistry, 2004
- Use of high-performance liquid chromatography to characterize the rapid decomposition of wortmannin in tissue culture mediaAnalytical Biochemistry, 2003
- Synthesis and in Vitro Evaluation of New Wortmannin Esters: Potent Inhibitors of Phosphatidylinositol 3-KinaseJournal of Medicinal Chemistry, 1996