Sox proteins: regulators of cell fate specification and differentiation
Top Cited Papers
- 15 October 2013
- journal article
- review article
- Published by The Company of Biologists in Development
- Vol. 140 (20), 4129-4144
- https://doi.org/10.1242/dev.091793
Abstract
Sox transcription factors play widespread roles during development; however, their versatile funtions have a relatively simple basis: the binding of a Sox protein alone to DNA does not elicit transcriptional activation or repression, but requires binding of a partner transcription factor to an adjacent site on the DNA. Thus, the activity of a Sox protein is dependent upon the identity of its partner factor and the context of the DNA sequence to which it binds. In this Primer, we provide an mechanistic overview of how Sox family proteins function, as a paradigm for transcriptional regulation of development involving multi-transcription factor complexes, and we discuss how Sox factors can thus regulate diverse processes during development.Keywords
This publication has 100 references indexed in Scilit:
- Sox9 Directs Hypertrophic Maturation and Blocks Osteoblast Differentiation of Growth Plate ChondrocytesDevelopmental Cell, 2012
- Disruption of SoxB1-Dependent Sonic hedgehog Expression in the Hypothalamus Causes Septo-optic DysplasiaDevelopmental Cell, 2012
- Eya1-Six1 Interaction Is Sufficient to Induce Hair Cell Fate in the Cochlea by Activating Atoh1 Expression in Cooperation with Sox2Developmental Cell, 2012
- Proteomic Analysis of Sox2-Associated Proteins During Early Stages of Mouse Embryonic Stem Cell Differentiation Identifies Sox21 as a Novel Regulator of Stem Cell FateThe International Journal of Cell Cloning, 2010
- The SoxD transcription factors – Sox5, Sox6, and Sox13 – are key cell fate modulatorsThe International Journal of Biochemistry & Cell Biology, 2010
- The Endoderm of the Mouse Embryo Arises by Dynamic Widespread Intercalation of Embryonic and Extraembryonic LineagesDevelopmental Cell, 2008
- Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem CellsCell, 2008
- Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined FactorsCell, 2006
- Comparative genomic and expression analysis of group B1 sox genes in zebrafish indicates their diversification during vertebrate evolutionDevelopmental Dynamics, 2006
- Core Transcriptional Regulatory Circuitry in Human Embryonic Stem CellsCell, 2005