Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A
- 1 March 1986
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 320 (6058), 134-139
- https://doi.org/10.1038/320134a0
Abstract
We have cloned and sequenced the complete complementary DNA of the oestrogen receptor (ER) present in the breast cancer cell line MCF-7. The expression of the ER cDNA in HeLa cells produces a protein that has the same relative molecular mass and binds oestradiol with the same affinity as the MCF-7 ER. There is extensive homology between the ER and the erb-A protein of the oncogenic avian erythroblastosis virus.Keywords
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