N-phosphorylation of amino acids by trimetaphosphate in aqueous solution—learning from prebiotic synthesis
- 17 February 2009
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Green Chemistry
- Vol. 11 (4), 569-573
- https://doi.org/10.1039/b817013d
Abstract
Inspired by a reactivity study between sodium trimetaphosphate (P3m) and amino acids in prebiotic chemistry, a one-step reaction with efficient purification procedure in aqueous media has been developed for the synthesis of N-phosphono-amino acids (NPAA). P3m was used to phosphorylate amino acids to NPAA with yields of 60∼91%. The by-products, inorganic polyphosphates, were recycled to regenerate the phosphorylation reagent P3m.This publication has 26 references indexed in Scilit:
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