Poststroke dementia is associated with recurrent ischaemic stroke
- 16 February 2013
- journal article
- cerebrovascular disease
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 84 (7), 722-726
- https://doi.org/10.1136/jnnp-2012-304084
Abstract
Objective To investigate whether poststroke dementia (PSD) diagnosed after ischaemic stroke predicts recurrent ischaemic stroke in long-term follow-up. Methods We included 486 consecutive patients with ischaemic stroke (388 with first-ever stroke) admitted to Helsinki University Central Hospital who were followed-up for 12 years. Dementia was diagnosed in 115 patients using the Diagnostic and Statistical Manual of Mental Disorders, 3rd edition (DSM-III) criteria. The effects of risk factors and PSD on survival free of recurrent stroke were estimated using Kaplan–Meier log-rank analyses, and the HRs for stroke recurrence were calculated using Cox proportional hazards models. Results In the entire cohort, patients with PSD had a shorter mean time to recurrent stroke (7.13 years, 95% CI 6.20 to 8.06) than patients without dementia (9.41 years, 8.89 to 9.92; log rank pConclusions Poststroke dementia predicts recurrence of ischaemic stroke in long-term follow-up and should be considered when estimating prognosis.This publication has 23 references indexed in Scilit:
- Post‐stroke delirium in relation to dementia and long‐term mortalityInternational Journal of Geriatric Psychiatry, 2011
- Cognitive impairment predicts poststroke death in long-term follow-upJournal of Neurology, Neurosurgery & Psychiatry, 2009
- Poststroke dementia predicts poor survival in long-term follow-up: influence of prestroke cognitive decline and previous strokeJournal of Neurology, Neurosurgery & Psychiatry, 2009
- Age related white matter changes predict stroke death in long term follow-upJournal of Neurology, Neurosurgery & Psychiatry, 2009
- Poststroke dementiaThe Lancet Neurology, 2005
- Impact of Age-Related Cerebral White Matter Changes on the Transition to Disability – The LADIS Study: Rationale, Design and MethodologyNeuroepidemiology, 2004
- Leukoaraiosis More Than Dementia Is a Predictor of Stroke RecurrenceStroke, 2003
- Dementia after stroke increases the risk of long‐term stroke recurrenceNeurology, 1997
- Comparison of Stroke Features and Disability in Daily Life in Patients With Ischemic Stroke Aged 55 to 70 and 71 to 85 YearsStroke, 1997
- Dementia associated with lacunar infarction.Stroke, 1992