Advances in understanding – genetic basis of intellectual disability
Open Access
- 7 April 2016
- journal article
- review article
- Published by F1000 Research Ltd in F1000Research
Abstract
Intellectual disability is the most common developmental disorder characterized by a congenital limitation in intellectual functioning and adaptive behavior. It often co-occurs with other mental conditions like attention deficit/hyperactivity disorder and autism spectrum disorder, and can be part of a malformation syndrome that affects other organs. Considering the heterogeneity of its causes (environmental and genetic), its frequency worldwide varies greatly. This review focuses on known genes underlying (syndromic and non-syndromic) intellectual disability, it provides a succinct analysis of their Gene Ontology, and it suggests the use of transcriptional profiling for the prioritization of candidate genes.Keywords
This publication has 77 references indexed in Scilit:
- A Noncoding, Regulatory Mutation Implicates HCFC1 in Nonsyndromic Intellectual DisabilityAmerican Journal of Human Genetics, 2012
- Network- and attribute-based classifiers can prioritize genes and pathways for autism spectrum disorders and intellectual disabilitySeminars in Medical Genetics, Part C of the American Journal of Medical Genetics, 2012
- Fragile X and X-Linked Intellectual Disability: Four Decades of DiscoveryAmerican Journal of Human Genetics, 2012
- Fine-Scale Survey of X Chromosome Copy Number Variants and Indels Underlying Intellectual DisabilityAmerican Journal of Human Genetics, 2010
- Normal Development of Brain CircuitsNeuropsychopharmacology, 2009
- A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardationNature Genetics, 2009
- Systematic and integrative analysis of large gene lists using DAVID bioinformatics resourcesNature Protocols, 2008
- Disorders of the genome architecture: a reviewGenomic Medicine, 2008
- Gene expression analyses reveal molecular relationships among 20 regions of the human CNSneurogenetics, 2006
- X-linked mental retardationNature Reviews Genetics, 2005