Successful treatment of a patient with takayasu arteritis using a humanized anti–interleukin‐6 receptor antibody
- 27 March 2008
- journal article
- case report
- Published by Wiley in Arthritis & Rheumatism
- Vol. 58 (4), 1197-1200
- https://doi.org/10.1002/art.23373
Abstract
Takayasu arteritis (TA) is a chronic inflammatory disease that involves the aorta and its major branches. Since overproduction of interleukin‐6 (IL‐6) seems to play a pathogenic role in TA, we used the anti–IL‐6 receptor (IL‐6R) antibody tocilizumab to treat a 20‐year‐old woman with refractory active TA complicated by ulcerative colitis (UC). Treatment with tocilizumab improved the clinical manifestations of TA and the abnormal laboratory findings in this patient and ameliorated the activity of UC. These results indicate that IL‐6R inhibition with tocilizumab might be a future treatment option for TA.Keywords
This publication has 12 references indexed in Scilit:
- Surgical Pathology of Noninfectious Ascending Aortitis: A Study of 45 Cases With Emphasis on an Isolated VariantThe American Journal of Surgical Pathology, 2006
- Serum cytokine profiles and their correlations with disease activity in Takayasu's arteritisRheumatology, 2005
- Anti–tumor necrosis factor therapy in patients with difficult to treat Takayasu arteritisArthritis & Rheumatism, 2004
- Treatment of rheumatoid arthritis with humanized anti–interleukin‐6 receptor antibody: A multicenter, double‐blind, placebo‐controlled trialArthritis & Rheumatism, 2004
- A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn’s diseaseGastroenterology, 2004
- Granulomatous vasculitisCurrent Rheumatology Reports, 2003
- Interleukin-6 and RANTES in Takayasu ArteritisCirculation, 1999
- Restricted Usage of T-Cell Receptor Vα-Vβ Genes in Infiltrating Cells in Aortic Tissue of Patients With Takayasu’s ArteritisCirculation, 1996
- Takayasu's Arteritis Associated with Ulcerative Colitis;Genetic Factors in this Association.Internal Medicine, 1996
- The American College of Rheumatology 1990 criteria for the classification of takayasu arteritisArthritis & Rheumatism, 1990