Comparison of 10 Perfusion MRI Parameters in 97 Sub-6-Hour Stroke Patients Using Voxel-Based Receiver Operating Characteristics Analysis
- 1 June 2009
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Stroke
- Vol. 40 (6), 2055-2061
- https://doi.org/10.1161/strokeaha.108.546069
Abstract
Background and Purpose— Perfusion-weighted imaging can predict infarct growth in acute stroke and potentially be used to select patients with tissue at risk for reperfusion therapies. However, the lack of consensus and evidence on how to best create PWI maps that reflect tissue at risk challenges comparisons of results and acute decision-making in trials. Deconvolution using an arterial input function has been hypothesized to generate maps of a more quantitative nature and with better prognostic value than simpler summary measures such as time-to-peak or the first moment of the concentration time curve. We sought to compare 10 different perfusion parameters by their ability to predict tissue infarction in acute ischemic stroke. Methods— In a retrospective analysis of 97 patients with acute stroke studied within 6 hours from symptom onset, we used receiver operating characteristics in a voxel-based analysis to compare 10 perfusion parameters: time-to-peak, first moment, cerebral blood volume and flow, and ...Keywords
This publication has 28 references indexed in Scilit:
- Inferring origin of vascular supply from tracer arrival timing patterns using bolus tracking MRIJournal of Magnetic Resonance Imaging, 2008
- Comparison of 10 Different Magnetic Resonance Perfusion Imaging Processing Methods in Acute Ischemic StrokeStroke, 2007
- Characterizing physiological heterogeneity of infarction risk in acute human ischaemic stroke using MRIBrain, 2006
- Perfusion-CT Assessment of Infarct Core and PenumbraStroke, 2006
- Outcome and Symptomatic Bleeding Complications of Intravenous Thrombolysis Within 6 Hours in MRI-Selected Stroke PatientsStroke, 2006
- Do Acute Diffusion- and Perfusion-Weighted MRI Lesions Identify Final Infarct Volume in Ischemic Stroke?Stroke, 2006
- Refining the Perfusion–Diffusion Mismatch HypothesisStroke, 2005
- Magnetic Resonance Imaging Criteria for Thrombolysis in Acute Cerebral InfarctStroke, 2005
- Perfusion-Weighted Magnetic Resonance Imaging Thresholds Identifying Core, Irreversibly Infarcted TissueStroke, 2003
- High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part I: Mathematical approach and statistical analysisMagnetic Resonance in Medicine, 1996