Resveratrol commonly displays hormesis: Occurrence and biomedical significance
- 29 November 2010
- journal article
- review article
- Published by SAGE Publications in Human & Experimental Toxicology
- Vol. 29 (12), 980-1015
- https://doi.org/10.1177/0960327110383625
Abstract
Resveratrol induces hormetic dose responses in a wide range of biological models, affecting numerous endpoints of biomedical and therapeutic significance. These responses were reported for numerous human tumor cell lines affecting breast, prostate, colon, lung, uterine and leukemia. In such cases, low concentrations of resveratrol enhanced tumor cell proliferation whereas higher concentrations were inhibitory. Similar resveratrol-induced biphasic dose responses were seen with several parasitic diseases, including Leishmaniasis and trichinella. Hormetic effects were also reported in animal models for cardiovascular induced injury, gastric lesions, ischemic stroke, Alzheimer’s disease and osteoporosis. In these cases, there was often a protective effect at low doses but an adverse effect at higher doses, exacerbating the disease process/incidence. This analysis indicates that many effects induced by resveratrol are dependent on dose and that opposite effects occur at low and high doses, being indicative of a hormetic dose response. Despite consistent occurrence of hormetic dose responses of resveratrol in a wide range of biomedical models, epidemiologic and clinical trials are needed to assess the nature of its dose-response in humans.Keywords
This publication has 146 references indexed in Scilit:
- Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1–uncoupling protein 2 pathwayNeuroscience, 2009
- Inhibition of mammary tumor growth and metastases to bone and liver by dietary grape polyphenolsClinical & Experimental Metastasis, 2009
- Nicotinamide Prevents NAD+ Depletion and Protects Neurons Against Excitotoxicity and Cerebral Ischemia: NAD+ Consumption by SIRT1 may Endanger Energetically Compromised NeuronsNeuroMolecular Medicine, 2009
- Dietary activators of Sirt1Molecular and Cellular Endocrinology, 2009
- Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by Akt‐dependent mechanismsBritish Journal of Pharmacology, 2008
- Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life SpanCell Metabolism, 2008
- Xenohormesis: Sensing the Chemical Cues of Other SpeciesCell, 2008
- Hormesis definedAgeing Research Reviews, 2008
- Resveratrol improves health and survival of mice on a high-calorie dietNature, 2006
- Pathways towards and away from Alzheimer's diseaseNature, 2004