Risk of Late Mortality and Second Malignant Neoplasms among 5-Year Survivors of Young Adult Cancer: A Report of the Childhood, Adolescent, and Young Adult Cancer Survivors Research Program
Open Access
- 12 September 2012
- journal article
- research article
- Published by Hindawi Limited in Journal of Cancer Epidemiology
- Vol. 2012, 1-11
- https://doi.org/10.1155/2012/103032
Abstract
We conducted a population-based retrospective study to assess the long-term risks of overall and cause-specific mortality and second malignant neoplasm (SMN) among survivors of young adult cancer compared to the risk in British Columbia (BC) population and to evaluate the effects of demographic and clinical factors on risk. 1248 5-year survivors of young adult cancer diagnosed 1970–1995 between 20 and 24 years of age were identified from the BC Cancer Registry and followed to the end of 2007. Standardized mortality ratios (SMRs) and standardized incidence ratios (SIRs) were calculated. The Cox proportional hazards model was used to estimate the effects of different demographic and disease-related characteristics on the risk of death and SMN. A total of 138 deaths and 62 SMNs were observed during follow-up. The overall SMR was 5.9 (95% CI 4.9–6.9) and the absolute excess risk was 5.3 per 1,000 person-years. The overall SIR was 3.0 (95% CI 2.3–3.8). Treatment with radiation resulted in increased risks of death and SMN. These observed increased risks emphasize the importance of prevention, surveillance, and treatment of late effects in survivors of young adult cancers.Keywords
Funding Information
- Canadian Cancer Society Research Institute (16000, 16001)
This publication has 31 references indexed in Scilit:
- Late effects in survivors of teenage and young adult cancer: does age matter?Annals of Oncology, 2011
- Childhood, adolescent, and young adult cancer survivors research program of British Columbia: Objectives, study design, and cohort characteristicsPediatric Blood & Cancer, 2010
- Radiation Dose and Breast Cancer Risk in the Childhood Cancer Survivor StudyJournal of Clinical Oncology, 2009
- Late Mortality Among 5-Year Survivors of Childhood Cancer: A Summary From the Childhood Cancer Survivor StudyJournal of Clinical Oncology, 2009
- Breast Cancer Surveillance Practices Among Women Previously Treated With Chest Radiation for a Childhood CancerJAMA, 2009
- Cause-Specific Late Mortality Among 5-Year Survivors of Childhood Cancer: The Childhood Cancer Survivor StudyJNCI Journal of the National Cancer Institute, 2008
- Risk of second malignancies in long-term survivors of childhood cancerEuropean Journal of Cancer, 2007
- Development of Risk-Based Guidelines for Pediatric Cancer Survivors: The Children's Oncology Group Long-Term Follow-Up Guidelines From the Children's Oncology Group Late Effects Committee and Nursing DisciplineJournal of Clinical Oncology, 2004
- Late mortality among five-year survivors of cancer in childhood and adolescence Differences between the Nordic CountriesActa Oncologica, 2004
- A Proportional Hazards Model for the Subdistribution of a Competing RiskJournal of the American Statistical Association, 1999