MPF-based meiotic cell cycle control: Half a century of lessons from starfish oocytes
Open Access
- 1 January 2018
- journal article
- review article
- Published by Japan Academy in Proceedings of the Japan Academy, Series B
- Vol. 94 (4), 180-203
- https://doi.org/10.2183/pjab.94.013
Abstract
In metazoans that undergo sexual reproduction, genomic inheritance is ensured by two distinct types of cell cycle, mitosis and meiosis. Mitosis maintains the genomic ploidy in somatic cells reproducing within a generation, whereas meiosis reduces by half the ploidy in germ cells to prepare for successive generations. The meiotic cell cycle is believed to be a derived form of the mitotic cell cycle; however, the molecular mechanisms underlying both of these processes remain elusive. My laboratory has long studied the meiotic cell cycle in starfish oocytes, particularly the control of meiotic M-phase by maturation- or M phase-promoting factor (MPF) and the kinase cyclin B-associated Cdk1 (cyclin B-Cdk1). Using this system, we have unraveled the molecular principles conserved in metazoans that modify M-phase progression from the mitotic type to the meiotic type needed to produce a haploid genome. Furthermore, we have solved a long-standing enigma concerning the molecular identity of MPF, a universal inducer of M-phase both in mitosis and meiosis of eukaryotic cells.Keywords
This publication has 172 references indexed in Scilit:
- Luteinizing hormone reduces the activity of the NPR2 guanylyl cyclase in mouse ovarian follicles, contributing to the cyclic GMP decrease that promotes resumption of meiosis in oocytesDevelopmental Biology, 2012
- Greatwall kinase and cyclin B-Cdk1 are both critical constituents of M-phase-promoting factorNature Communications, 2012
- Novel signaling mechanisms in the ovary during oocyte maturation and ovulationMolecular and Cellular Endocrinology, 2011
- Initiation of DNA replication after fertilization is regulated by p90Rsk at pre-RC/pre-IC transition in starfish eggsProceedings of the National Academy of Sciences of the United States of America, 2010
- Regulated activity of PP2A–B55δ is crucial for controlling entry into and exit from mitosis in Xenopus egg extractsThe EMBO Journal, 2009
- Greatwall maintains mitosis through regulation of PP2AThe EMBO Journal, 2009
- A relaxin-like peptide purified from radial nerves induces oocyte maturation and ovulation in the starfish, Asterina pectiniferaProceedings of the National Academy of Sciences of the United States of America, 2009
- PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylationNature, 2009
- Checking on DNA damage in S phaseNature Reviews Molecular Cell Biology, 2004
- Universal control mechanism regulating onset of M-phaseNature, 1990