Amniotic Membrane Transplantation for Ocular Surface Reconstruction
- 1 August 2005
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Cornea
- Vol. 24 (6), 643-653
- https://doi.org/10.1097/01.ico.0000151501.80952.c5
Abstract
The amniotic membrane, composed of 3 layers, the epithelium, basement membrane, and the stroma, was first used along with the chorion as a biologic membrane to promote healing of skin burns in 1910. In ophthalmology, it was used in 1940 in the management of conjunctival defects. Its revival in the 1990s was due to its ability to reduce ocular surface inflammation and scarring, promote rapid epithelialization due to the presence of growth factors, and antimicrobial properties. This has resulted in its application in several ocular disorders. A review of the literature shows that amniotic membrane is definitely beneficial in some but not all pathology. The future of amniotic membrane transplantation is very exciting, especially in the field of limbal stem cell research. However, further work is needed to elucidate whether it functions merely as a biologic contact lens or whether it has additional benefits.Keywords
This publication has 131 references indexed in Scilit:
- Outcome of surgery for recurrent pterygium using intraoperative application of mitomycin C and amniotic membrane transplantationJapanese Journal of Ophthalmology, 2003
- Corneal sensitivity and ocular surface changes following preserved amniotic membrane transplantation for nonhealing corneal ulcersEye, 2003
- Failure of amniotic membrane transplantation in the treatment of acute ocular burnsBritish Journal of Ophthalmology, 2001
- Amniotic membrane grafts, "fresh" or frozen? A clinical and in vitro comparisonBritish Journal of Ophthalmology, 2001
- Growth factor mRNA and protein in preserved human amniotic membraneCurrent Eye Research, 2000
- Suppression of TGF-ß signaling in both normal conjunctival fibroblasts and pterygial body fibroblasts by amniotic membraneCurrent Eye Research, 2000
- Amnion Epithelial Cells, in Contrast to Trophoblast Cells, Express All Classical HLA Class I Molecules Together With HLA‐GAmerican Journal of Reproductive Immunology, 1997
- The role of the basement membrane in differential expression of keratin proteins in epithelial cellsDevelopmental Biology, 1992
- An improved method to determine cell viability by simultaneous staining with fluorescein diacetate-propidium iodide.Journal of Histochemistry & Cytochemistry, 1985