Dietary sources of inorganic microparticles and their intake in healthy subjects and patients with Crohn's disease
Open Access
- 1 December 2004
- journal article
- Published by Cambridge University Press (CUP) in British Journal of Nutrition
- Vol. 92 (6), 947-955
- https://doi.org/10.1079/bjn20041276
Abstract
Dietary microparticles are non-biological, bacterial-sized particles. Endogenous sources are derived from intestinal Ca and phosphate secretion. Exogenous sources are mainly titanium dioxide (TiO2) and mixed silicates (Psil); they are resistant to degradation and accumulate in human Peyer's patch macrophages and there is some evidence that they exacerbate inflammation in Crohn's disease (CD). However, whether their intake differs between those with and without CD has not been studied. We aimed to identify dietary microparticle sources and intakes in subjects with and without CD. Patients with inactive CD and matched general practice-based controls (ninety-one per group) completed 7d food diaries. Intake data for dietary fibre and sucrose were compared as positive controls. All foods, pharmaceuticals and toothpastes were examined for microparticle content, and intakes of Ca and exogenous microparticles were compared between the two groups. Dietary intakes were significantly different between cases and controls for dietary fibre (12 (SD 5)v. 14 (sd 5) g/d;P=0.001) and sucrose (52 (sd 27)v. 45 (sd 18) g/d;P=0·04) but not for Ca. Estimated median TiO2and Psil intakes (2·5 and 35mg/individual per d respectively, totalling 1012–1013microparticles/individual per d) were broadly similar toper capitaestimates and while there was wide variation in intakes between individuals there was no significant difference between subjects with CD and controls. Hence, if exposure to microparticles is associated with the inflammation of CD, then the present study rules out excess intake as the problem. Nonetheless, microparticle-containing foods have now been identified which allows a low-microparticle diet to be further assessed in CD.Keywords
This publication has 39 references indexed in Scilit:
- Intake of dietary iron is low in patients with Crohn's disease: a case–control studyBritish Journal of Nutrition, 2004
- Probiotics and inflammatory bowel disease: from fads and fantasy to facts and futureBritish Journal of Nutrition, 2002
- Pre-, pro- and synbioticsCurrent Opinion in Clinical Nutrition and Metabolic Care, 2001
- Soluble Silica with High Affinity for Aluminum under Physiological and Natural ConditionsJournal of the American Chemical Society, 1997
- Possible use of food consumption surveys to estimate exposure to additivesFood Additives & Contaminants, 1996
- The approach adopted in the UK for the estimation of the intake of food additivesFood Additives & Contaminants, 1996
- Consumption of Refined Sugar by Patients with Crohn's Disease, Ulcerative Colitis, or Irritable Bowel SyndromeScandinavian Journal of Gastroenterology, 1983
- Diet in Crohn's diseaseDigestive Diseases and Sciences, 1981
- Consumption of refined carbohydrate by patients with Crohn’s disease in Tel-Aviv-YafoPublished by Oxford University Press (OUP) ,1980
- Dentifrice Usage and Ingestion Among Four Age GroupsJournal of Dental Research, 1974