Immunocompromised Hosts: Immunopharmacology of Modern Antifungals
Open Access
- 15 July 2008
- journal article
- review article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 47 (2), 226-235
- https://doi.org/10.1086/589290
Abstract
In addition to their in vitro inhibitory and fungicidal effects, modern antifungal agents interact in vivo with host immune functions involved in defense against fungal pathogens. The nature of such interactions is diverse and depends on the drug, the immunological status of the host, and the fungal pathogen. Given the prominent role of the host's immune response in controlling invasive fungal infection, immunomodulation by antifungal drugs may prove to be clinically significant. Elucidation of the immunopharmacology of these drugs may aid in designing therapeutic regimens for specific clinical scenarios associated with defined immunological dysfunction.Keywords
This publication has 89 references indexed in Scilit:
- Pretreatment with Empty Liposomes Attenuates the Immunopathology of Invasive Pulmonary Aspergillosis in Corticosteroid-Immunosuppressed MiceAntimicrobial Agents and Chemotherapy, 2007
- Histoplasma capsulatumα-(1,3)-glucan blocks innate immune recognition by the β-glucan receptorProceedings of the National Academy of Sciences, 2007
- Dectin-1 is required for β-glucan recognition and control of fungal infectionNature Immunology, 2006
- Early Neutrophil Recruitment and Aggregation in the Murine Lung Inhibit Germination ofAspergillus fumigatusConidiaInfection and Immunity, 2006
- Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptorsJCI Insight, 2006
- A Drug-Sensitive Genetic Network Masks Fungi from the Immune SystemPLoS Pathogens, 2006
- Differential Expression of Cytokines and Chemokines in Human Monocytes Induced by Lipid Formulations of Amphotericin BAntimicrobial Agents and Chemotherapy, 2005
- The damage-response framework of microbial pathogenesisNature Reviews Microbiology, 2003
- Amphotericin B both inhibits and enhances T-cell proliferation: Inhibitory effect is mediated through H2O2 production via cyclooxygenase pathway by macrophagesJournal of Cellular Biochemistry, 2000
- Infusion‐related toxicity of three different amphotericin B formulations and its relation to cytokine plasma levelsMycoses, 1995