A comparison of changes in the nucleus basalis and locus caeruleus in Alzheimer's disease.
Open Access
- 1 February 1984
- journal article
- research article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 47 (2), 201-203
- https://doi.org/10.1136/jnnp.47.2.201
Abstract
In 22 patients with Alzheimer's disease loss of neurons from the nucleus basalis of Meynert and locus caeruleus averaged 58% and 71% respectively with nucleolar volume being reduced by 30% in both. These changes were greater in those patients under 80 years of age and in such patients damage to the locus was more severe than that to the nucleus basalis. In older patients (over 80 years) changes were similar in extent in both regions.Keywords
This publication has 21 references indexed in Scilit:
- A quantitative study of cerebral atrophy in old age and senile dementiaJournal of the Neurological Sciences, 1981
- Cell loss in the locus coeruleus in senile dementia of Alzheimer typeJournal of the Neurological Sciences, 1981
- Reduced dopamine-beta-hydroxylase activity in Alzheimer's diseaseBMJ, 1981
- Changes in the Monoamine Containing Neurones of the Human Cns in Senile DementiaThe British Journal of Psychiatry, 1980
- Computed Tomography in the Elderly 2. Senile Dementia: Diagnosis and Functional ImpairmentThe British Journal of Psychiatry, 1980
- Neurotransmitter-related enzymes in senile dementia of the alzheimer typeBrain Research, 1979
- ACCELERATED AGEING OR SELECTIVE NEURONAL LOSS AS AN IMPORTANT CAUSE OF DEMENTIA?The Lancet, 1979
- Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.BMJ, 1978
- Neurotransmitter enzyme abnormalities in senile dementiaJournal of the Neurological Sciences, 1977
- NEOCORTICAL CHOLINERGIC NEURONS IN ELDERLY PEOPLEThe Lancet, 1977