Evolutionary origins of oxygen sensing in animals
Open Access
- 26 November 2010
- journal article
- editorial
- Published by Springer Science and Business Media LLC in EMBO Reports
- Vol. 12 (1), 3-4
- https://doi.org/10.1038/embor.2010.192
Abstract
Oxygen is required for aerobic energy production but its levels have to be tightly regulated to avoid deleterious effects. Thus, animals have evolved mechanisms to monitor and respond to fluctuations in oxygen availability. Here, the evolution of the HIF system is discussed in light of a report that reveals its presence in the simplest animal.Keywords
This publication has 10 references indexed in Scilit:
- The hypoxia‐inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerensEMBO Reports, 2010
- Regulation of hypoxia adaptation: an overlooked virulence attribute of pathogenic fungi?Medical Mycology, 2010
- Cross-Kingdom Comparison of Transcriptomic Adjustments to Low-Oxygen Stress Highlights Conserved and Plant-Specific ResponsesPlant Physiology, 2010
- Hypoxia-inducible Factor Prolyl-4-hydroxylase PHD2 Protein Abundance Depends on Integral Membrane Anchoring of FKBP38Published by Elsevier BV ,2009
- Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase PathwayMolecular Cell, 2008
- Oxygen-regulated degradation of fission yeast SREBP by Ofd1, a prolyl hydroxylase family memberThe EMBO Journal, 2008
- Prolyl 4-hydroxylase-1 mediates O2 signaling during development ofDictyosteliumDevelopment, 2007
- PAS Domains: Internal Sensors of Oxygen, Redox Potential, and LightMicrobiology and Molecular Biology Reviews, 1999