Inhaling medicines: delivering drugs to the body through the lungs
Top Cited Papers
- 1 January 2007
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Drug Discovery
- Vol. 6 (1), 67-74
- https://doi.org/10.1038/nrd2153
Abstract
Remarkably, with the exception of anaesthetic gases, the ancient human practice of inhaling substances into the lungs for systemic effect has only just begun to be adopted by modern medicine. Treatment of asthma by inhaled drugs began in earnest in the 1950s, and now such 'topical' or targeted treatment with inhaled drugs is considered for treating many other lung diseases. More recently, major advances have led to increasing interest in systemic delivery of drugs by inhalation. Small molecules can be delivered with very rapid action, low metabolism and high bioavailability; and macromolecules can be delivered without injections, as highlighted by the recent approval of the first inhaled insulin product. Here, we review these advances, and discuss aspects of lung physiology and formulation composition that influence the systemic delivery of inhaled therapeutics.Keywords
This publication has 62 references indexed in Scilit:
- Delivery of an Erythropoietin-Fc Fusion Protein by Inhalation in Humans through an Immunoglobulin Transport PathwayJournal of Aerosol Medicine, 2005
- In vitro and in vivo methotrexate disposition in alveolar macrophages: Comparison of pharmacokinetic parameters of two formulationsInternational Journal of Pharmaceutics, 2005
- Pharmacokinetics and Acute Safety of Inhaled Testosterone in Postmenopausal WomenThe Journal of Clinical Pharmacology, 2005
- Respirable Microspheres for InhalationClinical Pharmacokinetics, 2005
- COMORBID CONDITIONSHeadache: The Journal of Head and Face Pain, 2005
- Alveolar macrophages are a primary barrier to pulmonary absorption of macromoleculesAmerican Journal of Physiology-Lung Cellular and Molecular Physiology, 2004
- Clinical Pharmacokinetics and Pharmacodynamics of Inhaled InsulinClinical Pharmacokinetics, 2004
- Use of amphotericin B aerosols for the prevention of pulmonary aspergillosisInfection, 1994
- Pulmonary Delivery of Liposomal DrugsJournal of Liposome Research, 1994
- Intranasal Aerosolized InsulinNew England Journal of Medicine, 1985