Ten-year risk of cardiovascular incidence related to diabetes, prediabetes, and the metabolic syndrome
Open Access
- 6 March 2007
- journal article
- Published by Elsevier BV in American Heart Journal
- Vol. 153 (4), 552-558
- https://doi.org/10.1016/j.ahj.2007.01.003
Abstract
The relative contributions of the metabolic syndrome (MetS) and dysglycemia on the risk of cardiovascular disease (CVD) have not been dissected. We aimed to compare MetS with dysglycemia in their association with the 10-year incidence risk of CVD. A total of 30,378 subjects were recruited from 11 provinces in the CMCS and followed-up for new coronary heart disease (CHD) and stroke events (ischemic stroke and hemorrhagic stroke) for 10 years. Incidence rates and HRs were estimated by the presence or absence of MetS, impaired fasting glucose (IFG) and diabetes, and by the various traits of MetS. Among the subjects, 18.2% were defined as having MetS; 21.1% had IFG, and 6.8% had diabetes. Metabolic syndrome prevalence in IFG and diabetes was 38.1% and 48.7%, respectively, and the prevalence of IFG and diabetes in MetS was 44.1% and 18.3%, respectively. After adjusting for nonmetabolic risk factors, HRs of total CVD, CHD, and ischemic stroke in MetS were significant and higher than those in non-MetS, regardless of glycemic status. In the absence of MetS, the impact of dysglycemia was found only in IFG to CHD and diabetes to ischemic stroke. Hyperglycemia without any concomitant disorders was not associated with significantly higher risk of CVD. The increased CVD risk in individuals with IFG or diabetes was largely driven by the coexistence of multiple metabolic disorders rather than hyperglycemia per se. Identification of clustering of metabolic abnormalities should be given more consideration in CVD prevention.Keywords
This publication has 26 references indexed in Scilit:
- Ethnic-Specific Criteria for the Metabolic SyndromeDiabetes Care, 2006
- Is China facing an obesity epidemic and the consequences? The trends in obesity and chronic disease in ChinaInternational Journal of Obesity, 2006
- Prehypertension, Diabetes, and Cardiovascular Disease Risk in a Population-Based SampleHypertension, 2006
- Metabolic Syndrome as a Precursor of Cardiovascular Disease and Type 2 Diabetes MellitusCirculation, 2005
- Diagnosis and Management of the Metabolic SyndromeCirculation, 2005
- Impact of the Metabolic Syndrome on Mortality From Coronary Heart Disease, Cardiovascular Disease, and All Causes in United States AdultsCirculation, 2004
- Trends in Stroke and Coronary Heart Disease in the WHO MONICA ProjectStroke, 2003
- Treatment with Atorvastatin to the National Cholesterol Educational Program Goal Versus 'Usual' Care in Secondary Coronary Heart Disease PreventionCurrent Medical Research and Opinion, 2002
- Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)The Lancet, 1998
- Monitoring of Cardiovascular Disease and Risk Factor Trends: Experiences from the WHO/MONICA ProjectAnnals of Medicine, 1994