Discovery and development of the anticancer agent salinosporamide A (NPI-0052)
Top Cited Papers
- 15 March 2009
- journal article
- Published by Elsevier BV in Bioorganic & Medicinal Chemistry
- Vol. 17 (6), 2175-2180
- https://doi.org/10.1016/j.bmc.2008.10.075
Abstract
No abstract availableKeywords
This publication has 42 references indexed in Scilit:
- Proteasome Inhibition Activates Epidermal Growth Factor Receptor (EGFR) and EGFR-Independent Mitogenic Kinase Signaling Pathways in Pancreatic Cancer CellsClinical Cancer Research, 2008
- Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myelomaBlood, 2008
- Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-κB–regulated gene productsBlood, 2007
- NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cellsBlood, 2007
- Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropicaProceedings of the National Academy of Sciences of the United States of America, 2007
- Concise Total Synthesis of (±)-Salinosporamide A, (±)-Cinnabaramide A, and Derivatives via a Bis-cyclization Process: Implications for a Biosynthetic Pathway?Organic Letters, 2007
- Salinispora arenicola gen. nov., sp. nov. and Salinispora tropica sp. nov., obligate marine actinomycetes belonging to the family MicromonosporaceaeInternational Journal of Systematic and Evolutionary Microbiology, 2005
- Bioactive Microbial MetabolitesThe Journal of Antibiotics, 2005
- Salinosporamide A: A Highly Cytotoxic Proteasome Inhibitor from a Novel Microbial Source, a Marine Bacterium of the New Genus SalinosporaAngewandte Chemie, 2003
- Structure of 20S proteasome from yeast at 2.4Å resolutionNature, 1997