Male development of chromosomally female mice transgenic for Sry
- 9 May 1991
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 351 (6322), 117-121
- https://doi.org/10.1038/351117a0
Abstract
The initiation of male development in mammals requires one or more genes on the Y chromosome. A recently isolated gene, termed SRY in humans and Sry in mouse, has many of the genetic and biological properties expected of a Y-located testis-determining gene. It is now shown that Sry on a 14-kilobase genomic DNA fragment is sufficient to induce testis differentiation and subsequent male development when introduced into chromosomally female mouse embryos.Keywords
This publication has 34 references indexed in Scilit:
- A human XY female with a frame shift mutation in the candidate testis-determining gene SRYNature, 1990
- Expression of a candidate sex-determining gene during mouse testis differentiationNature, 1990
- Genetic evidence equating SRY and the testis-determining factorNature, 1990
- A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motifNature, 1990
- A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genesNature, 1990
- Somatic and germ-cell sex in mammalsPhilosophical Transactions of the Royal Society of London. B, Biological Sciences, 1988
- Sex determination in mammalsTrends in Genetics, 1988
- THE Y-CHROMOSOME AS THE BEARER OF MALE DETERMINING FACTORS IN THE MOUSEProceedings of the National Academy of Sciences of the United States of America, 1959
- A SEX-CHROMOSOME ANOMALY IN A CASE OF GONADAL DYSGENESIS (TURNER'S SYNDROME)The Lancet, 1959
- A Case of Human Intersexuality Having a Possible XXY Sex-Determining MechanismNature, 1959