Towards building a chromosome segregation machine
- 27 January 2010
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 463 (7280), 446-456
- https://doi.org/10.1038/nature08912
Abstract
All organisms, from bacteria to humans, face the daunting task of replicating, packaging and segregating up to two metres (about 6 × 109 base pairs) of DNA when each cell divides. This task is carried out up to a trillion times during the development of a human from a single fertilized cell. The strategy by which DNA is replicated is now well understood. But when it comes to packaging and segregating a genome, the mechanisms are only beginning to be understood and are often as variable as the organisms in which they are studied.This publication has 93 references indexed in Scilit:
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