The adverse effects of antiepileptic drugs in children
- 4 May 2007
- journal article
- review article
- Published by Taylor & Francis Ltd in Expert Opinion on Drug Safety
- Vol. 6 (3), 251-265
- https://doi.org/10.1517/14740338.6.3.251
Abstract
Efficacy of antiepileptic drugs (AEDs) are often equivalent, hence selection of an AED is often determined by the adverse effects (AEs). The development of neurocognitive AEs is almost inevitable with use of AEDs, especially in high-risk groups. Teratogenesis with major or minor malformations is of great concern during the first trimester of pregnancy, but an increasing body of information suggests that potential neurocognitive developmental delay may also occur with use of AEDs in the latter part of pregnancy. Decreased bone mineral density has been found in adults and children receiving both enzyme-inducing AEDs and valproate, an enzyme-inhibiting drug. AEDs may influence the lipid profile, body weight, reproductive, hormonal and other endocrine functions, and sleep architecture. There are age-specific AEs related to pharmacokinetic differences that have been highlighted in this review with emphasis on the pediatric population. A classification of AEs using different parameters is also included.Keywords
This publication has 119 references indexed in Scilit:
- In utero antiepileptic drug exposureNeurology, 2006
- Safety of the newer antiepileptic drug oxcarbazepine during pregnancyCurrent Medical Research and Opinion, 2005
- EURAP: An International Registry of Antiepileptic Drugs and PregnancyEpilepsia, 2004
- The teratogenicity of anticonvulsant drugs: a progress reportJournal of Medical Genetics, 2002
- The Efficacy of Lamotrigine in Children and Adolescents with Refractory Generalized Epilepsy: A Randomized, Double‐Blind, Crossover StudyEpilepsia, 1998
- New drugs for epilepsyCurrent Opinion in Neurology, 1998
- Gabapentin Associated with Aggressive Behavior in Pediatric Patients with SeizuresEpilepsia, 1996
- Effect of carbamazepine and valproate on bone mineral densityThe Journal of Pediatrics, 1995
- Effects of anti-epileptic drug therapy on bone mineral density in ambulatory epileptic childrenBrain & Development, 1994
- Comparison of Carbamazepine, Phenobarbital, Phenytoin, and Primidone in Partial and Secondarily Generalized Tonic–Clonic SeizuresNew England Journal of Medicine, 1985