Complete Nucleotide Sequence of Klebsiella pneumoniae Multidrug Resistance Plasmid pKP048, Carrying bla KPC-2 , bla DHA-1 , qnrB4 , and armA
Open Access
- 1 September 2010
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 54 (9), 3967-3969
- https://doi.org/10.1128/aac.00137-10
Abstract
The Klebsiella pneumoniae multidrug resistance plasmid pKP048 was completely sequenced. This plasmid carries several important resistance determinants, such as blaKPC-2, blaDHA-1, qnrB4, and armA, which confer resistance to carbapenems, cephalosporins, fluoroquinolones, and aminoglycosides, respectively. Analysis of the finished 151,188-bp sequence data revealed 163 putative genes, 108 of which were assigned functions such as replication, stable inheritance, antibiotic resistance, a mobile element, conjugal transfer, and a restriction-modification system, showing the strong phylogenetic mosaicism and plasticity of the plasmid.Keywords
This publication has 17 references indexed in Scilit:
- Novel Genetic Environment of the Carbapenem-Hydrolyzing β-Lactamase KPC-2 among Enterobacteriaceae in ChinaAntimicrobial Agents and Chemotherapy, 2009
- Genetic Organization of Transposase Regions Surrounding bla KPC Carbapenemase Genes on Plasmids from Klebsiella Strains Isolated in a New York City HospitalAntimicrobial Agents and Chemotherapy, 2009
- Plasmid-Mediated 16S rRNA Methylases among Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae IsolatesAntimicrobial Agents and Chemotherapy, 2008
- Sequence of Conjugative Plasmid pIP1206 Mediating Resistance to Aminoglycosides by 16S rRNA Methylation and to Hydrophilic Fluoroquinolones by EffluxAntimicrobial Agents and Chemotherapy, 2008
- Colistin susceptibility testing by Etest and disk diffusion methodsInternational Journal of Antimicrobial Agents, 2008
- Plasmid-mediated 16S rRNA methylases conferring high-level aminoglycoside resistance in Escherichia coli and Klebsiella pneumoniae isolates from two Taiwanese hospitalsJournal of Antimicrobial Chemotherapy, 2004
- Novel Carbapenem-Hydrolyzing β-Lactamase, KPC-1, from a Carbapenem-Resistant Strain ofKlebsiella pneumoniaeAntimicrobial Agents and Chemotherapy, 2001
- Novel transferable beta-lactam resistance with cephalosporinase characteristics in Salmonella enteritidisJournal of Antimicrobial Chemotherapy, 1997
- Nucleotide sequence and characterization of erythromycin resistance determinant that encodes macrolide 2'-phosphotransferase I in Escherichia coliAntimicrobial Agents and Chemotherapy, 1995
- A Salmonella dublin virulence plasmid locus that affects bacterial growth under nutrient‐limited conditionsMolecular Microbiology, 1992