The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris
- 21 January 2014
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science Signaling
- Vol. 7 (309), ra9
- https://doi.org/10.1126/scisignal.2004754
Abstract
Enhancing TFE3 activity to promote expression of lysosome-associated genes may be beneficial in treating lysosomal storage disorders.Keywords
This publication has 64 references indexed in Scilit:
- Transcription factor EB (TFEB) is a new therapeutic target for Pompe diseaseEMBO Molecular Medicine, 2013
- Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1Cell, 2012
- A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEBThe EMBO Journal, 2012
- Embryonic expression of zebrafish MiT family genes tfe3b, tfeb, and tfecDevelopmental Dynamics, 2011
- Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular ClearanceDevelopmental Cell, 2011
- Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino AcidsCell, 2010
- A Multiparameter Network Reveals Extensive Divergence between C. elegans bHLH Transcription FactorsCell, 2009
- Transcription factors TFE3 and TFEB are critical for CD40 ligand expression and thymus-dependent humoral immunityNature Immunology, 2006
- A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeastNature, 2006
- Rheb is an essential regulator of S6K in controlling cell growth in DrosophilaNature, 2003