Increased resting and evoked release of transmitter following repetitive electrical tetanization in hippocampus: a biochemical correlate to long-lasting synaptic potentiation
- 10 March 1981
- journal article
- research article
- Published by Elsevier BV in Brain Research
- Vol. 208 (2), 436-441
- https://doi.org/10.1016/0006-8993(81)90573-4
Abstract
In vitro stimulation of two axonal branches from hippocampal CA3 pyramids, the CA1 afferent Schaffer collaterals and the CA3 efferents to septum through fimbria, released d-[3H]aspartate as a measure for endogenous l-glutamate. Following bursts of repetitive electrical stimuli to the Schaffer collaterals, a long-lasting and significantly increased resting efflux, as well as an increased stimulus evoked release of d-aspartate, appeared. No such persistent increase in d-aspartate efflux was recorded from the septal terminals. We propose that increased transmitter liberation may account for long-term synaptic potentiation in hippocampus.Keywords
This publication has 16 references indexed in Scilit:
- Regulation of glutamate receptors by cationsNature, 1979
- Calcium dependency of synaptic long‐lasting potentiation in the hippocampal sliceActa Physiologica Scandinavica, 1979
- Synaptic transmission is required for initiation of long-term potentiationBrain Research, 1978
- Heterosynaptic depression: a postsynaptic correlate of long-term potentiationNature, 1977
- Specific long-lasting potentiation of synaptic transmission in hippocampal slicesNature, 1977
- Long term potentiation is accompanied by a reduction in dendritic responsiveness to glutamic acidNature, 1976
- Long-term and short-term plasticity in the CA1, CA3, and dentate regions of the rat hippocampal sliceBrain Research, 1976
- UPTAKE AND RELEASE OF D‐ AND L‐ASPARTATE BY RAT BRAIN SLICESJournal of Neurochemistry, 1976
- Long-lasting facilitation of a synaptic potential following tetanization in thein vitro hippocampal sliceBrain Research, 1975
- Long-term potentiation of the perforant path-granule cell synapse in the rat hippocampusBrain Research, 1975