Interocular Asymmetry of Foveal Thickness in Parkinson Disease
Open Access
- 1 January 2012
- journal article
- research article
- Published by Hindawi Limited in Journal of Ophthalmology
- Vol. 2012, 1-6
- https://doi.org/10.1155/2012/728457
Abstract
Purpose. To quantify interocular asymmetry (IA) of foveal thickness in Parkinson disease (PD) versus that of controls.Design. Prospective case-control series.Methods.In vivoassessment of foveal thickness of 46 eyes of 23 PD patients and 36 eyes of 18 control subjects was studied using spectral domain optical coherence tomography (SD-OCT). Inner versus outer layer retinal segmentation and macular volumes were quantified using the manufacturer's software, while foveal thickness was measured using the raw data from each eye in a grid covering a 6 by 6 mm area centered on the foveola in 0.25 mm steps. Thickness data were entered into MATLAB software.Results. Macular volumes differed significantly at the largest (Zone 3) diameter centered on the foveola (ETDRS protocol). By segmenting inner from outer layers, we found that the IA in PD is mostly due to changes on the slope of the foveal pit at the radial distances of 0.5 and 0.75 mm (1.5 mm and 1 mm diameter).Conclusions. About half of the PD patients had IA of the slope of the foveal pit. IA is a potentially useful marker of PD and is expected to be comparable across different SD-OCT equipment. Data of larger groups may be developed in future multicenter studies.Funding Information
- National Institute of Neurological Disorders and Stroke (53947, 55376)
This publication has 27 references indexed in Scilit:
- Comparison of Retinal Nerve Fiber Layer and Central Macular Thickness Measurements Among Five Different Optical Coherence Tomography Instruments in Patients With Multiple Sclerosis and Optic NeuritisJournal of Neuro-Ophthalmology, 2011
- Inner Retinal Layer Thinning in Parkinson DiseaseAmerican Journal of Ophthalmology, 2009
- The mystery of motor asymmetry in Parkinson's diseaseThe Lancet Neurology, 2006
- Parkinson diseaseNeurology, 2005
- Neurobiology of retinal dopamine in relation to degenerative states of the tissueVision Research, 1997
- Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.Journal of Neurology, Neurosurgery & Psychiatry, 1992
- Functional neuroarchitecture of the retina: hypothesis on the dysfunction of retinal dopaminergic circuitry in Parkinson's diseaseSurgical and Radiologic Anatomy, 1988
- Alteration of visual evoked potentials and electroretinograms in Parkinson's diseaseElectroencephalography and Clinical Neurophysiology, 1987
- Shall We Count Numbers of Eyes or Numbers of Subjects?American Journal of Ophthalmology, 1973
- ParkinsonismNeurology, 1967