Food commensal microbes as a potentially important avenue in transmitting antibiotic resistance genes
Open Access
- 1 January 2006
- journal article
- Published by Oxford University Press (OUP) in FEMS Microbiology Letters
- Vol. 254 (2), 226-231
- https://doi.org/10.1111/j.1574-6968.2005.00030.x
Abstract
The rapid emergence of antibiotic-resistant (ART) pathogens is a major threat to public health. While the surfacing of ART food-borne pathogens is alarming, the magnitude of the antibiotic resistance (AR) gene pool in food-borne commensal microbes is yet to be revealed. Incidence of ART commensals in selected retail food products was examined in this study. The presence of 102–107 CFU of ART bacteria per gram of foods in many samples, particularly in ready-to-eat, ‘healthy’ food items, indicates that the ART bacteria are abundant in the food chain. AR-encoding genes were detected in ART isolates, and Streptococcus thermophilus was found to be a major host for AR genes in cheese microbiota. Lactococcus lactis and Leuconostoc sp. isolates were also found carrying AR genes. The data indicate that food could be an important avenue for ART bacterial evolution and dissemination. AR-encoding plasmids from several food-borne commensals were transmitted to Streptococcus mutans via natural gene transformation under laboratory conditions, suggesting the possible transfer of AR genes from food commensals to human residential bacteria via horizontal gene transfer.Keywords
This publication has 18 references indexed in Scilit:
- High-Frequency Conjugation System Facilitates Biofilm Formation and pAMβ1 Transmission by Lactococcus lactisApplied and Environmental Microbiology, 2005
- Enhanced in vivo fitness of fluoroquinolone-resistant Campylobacter jejuni in the absence of antibiotic selection pressureProceedings of the National Academy of Sciences of the United States of America, 2005
- Quantification of Tetracycline Resistance Genes in Feedlot Lagoons by Real-Time PCRApplied and Environmental Microbiology, 2004
- Human intestinal bacteria as reservoirs for antibiotic resistance genesTrends in Microbiology, 2004
- Genetic Basis of Erythromycin Resistance in Oral BacteriaAntimicrobial Agents and Chemotherapy, 2004
- Gram-positive bacteria are a major reservoir of Class 1 antibiotic resistance integrons in poultry litterProceedings of the National Academy of Sciences of the United States of America, 2004
- Resistance to Macrolide, Lincosamide, Streptogramin, Ketolide, and Oxazolidinone AntibioticsMolecular Biotechnology, 2004
- Prevalence, Proportions, and Identities of Antibiotic-Resistant Bacteria in the Oral Microflora of Healthy ChildrenMicrobial Drug Resistance, 2003
- Animal antibiotic use has an early but important impact on the emergence of antibiotic resistance in human commensal bacteriaProceedings of the National Academy of Sciences of the United States of America, 2002
- Changes in Intestinal Flora of Farm Personnel after Introduction of a Tetracycline-Supplemented Feed on a FarmThe New England Journal of Medicine, 1976