Effects of Interferon on Sensitive and Resistant L1210 Cell Lines.
- 1 February 1981
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Interferon Research
- Vol. 1 (2), 287-295
- https://doi.org/10.1089/jir.1981.1.287
Abstract
L1210 cells resistant to the antiviral and anticellular effects of interferon are not inducible for the 2,5A synthetase and for the protein kinase activities. Cloning of one resistant L1210 strain has revealed heterogeneity of the cell population with respect to their antiviral and anticellular response as well as protein kinase and 2,5A synthetase inducibility. The defect in the response of truly interferon-resistant L1210 cells appears to reside at an early step of interferon action.Keywords
This publication has 14 references indexed in Scilit:
- Mouse fibroblast (type I) and immune (type II) interferons: pronounced differences in affinity for gangliosides and in antiviral and antigrowth effects on mouse leukemia L-1210R cells.Proceedings of the National Academy of Sciences of the United States of America, 1980
- High-affinity binding of 125I-labelled mouse interferon to a specific cell surface receptorNature, 1980
- Intracellular Events in Interferon-Treated CellsDifferentiation, 1979
- Interferon action: induction of specific proteins in mouse and human cells by homologous interferons.Proceedings of the National Academy of Sciences of the United States of America, 1979
- Interferon-induced enzymatic activities and their role in the antiviral stateCell, 1979
- Accumulation of an mRNA and protein in interferon-treated Ehrlich ascites tumour cellsNature, 1979
- Fibroblast interferon induces synthesis of four proteins in human fibroblast cells.Proceedings of the National Academy of Sciences of the United States of America, 1979
- Induction of 2′5′-oligoadenylate synthetase activity and a new protein by chick interferonVirology, 1979
- Mechanisms of Interferon Induced Transfer of Viral Resistance Between Animal CellsJournal of General Virology, 1979
- Comparison of Interferon Action in Interferon Resistant and Sensitive L1210 CellsJournal of General Virology, 1978