Mortality Associated With Acute Charcot Foot and Neuropathic Foot Ulceration
Open Access
- 25 February 2010
- journal article
- Published by American Diabetes Association in Diabetes Care
- Vol. 33 (5), 1086-1089
- https://doi.org/10.2337/dc09-1428
Abstract
OBJECTIVE: To compare the mortality of patients with an acute Charcot foot with a matched population with uninfected neuropathic foot ulcers (NFUs). RESEARCH DESIGN AND METHODS: Data were extracted from a specialist departmental database, supplemented by hospital records. The findings were compared with the results of earlier populations with Charcot foot and uninfected NFUs managed from 1980. Finally, the results of all patients with acute Charcot foot and all control subjects managed between 1980 and 2007 were compared with normative mortality data for the U.K. population. RESULTS: A total of 70 patients presented with an acute Charcot foot (mean age 57.4 ± 12.0 years; 48 male [68.6%]) between 2001 and 2007; there were 66 matched control subjects. By 1 October 2008, 13 (eight male; 18.6%) patients with a Charcot foot had died, after a median of 2.1 years (interquartile range 1.1–3.3). Twenty-two (20 male; 33.3%) control subjects had also died after a median of 1.3 years (0.6–2.5). There was no difference in survival between the two groups (log-rank P > 0.05). Median survival of all 117 patients with acute Charcot foot managed between 1980 and 2007 was 7.88 years (4.0–15.4) and was not significantly different from the control NFU patients (8.43 years [3.4–15.8]). When compared with normative U.K. population data, life expectancy in the two groups was reduced by 14.4 and 13.9 years, respectively. CONCLUSIONS: These data confirm that the mortality in patients presenting to our unit with either an acute Charcot foot and an uninfected neuropathic ulcer was unexpectedly high.Keywords
This publication has 13 references indexed in Scilit:
- Mortality Risk of Charcot Arthropathy Compared With That of Diabetic Foot Ulcer and Diabetes AloneDiabetes Care, 2009
- Improved Survival of Diabetic Foot Ulcer Patients 1995–2008Diabetes Care, 2008
- Mortality Rates and Diabetic Foot UlcersJournal of the American Podiatric Medical Association, 2008
- Associations of Diabetes Mellitus With Total Life Expectancy and Life Expectancy With and Without Cardiovascular DiseaseArchives of Internal Medicine, 2007
- Mortality in patients with diabetic neuropathic osteoarthropathy (Charcot foot)Diabetic Medicine, 2004
- Validation of a system of foot ulcer classification in diabetes mellitusDiabetic Medicine, 2004
- Amputation and Mortality in New-Onset Diabetic Foot Ulcers Stratified by EtiologyDiabetes Care, 2003
- Long-term follow-up in diabetic Charcot feet with spontaneous onset.Diabetes Care, 2000
- Showing neuropathy is related to increased mortality in diabetic patients — a survival analysis using an accelerated failure time modelJournal of Clinical Epidemiology, 2000
- Risk factors for mortality in Type II (non-insulin-dependent) diabetes: evidence of a role for neuropathy and a protective effect of HLA-DR4Diabetologia, 1998