Regulation of Wound Healing by Growth Factors and Cytokines
Top Cited Papers
- 1 July 2003
- journal article
- review article
- Published by American Physiological Society in Physiological Reviews
- Vol. 83 (3), 835-870
- https://doi.org/10.1152/physrev.2003.83.3.835
Abstract
Werner, Sabine, and Richard Grose. Regulation of Wound Healing by Growth Factors and Cytokines. Physiol Rev 83: 835–870, 2003; 10.1152/physrev.00032.2002.—Cutaneous wound healing is a complex process involving blood clotting, inflammation, new tissue formation, and finally tissue remodeling. It is well described at the histological level, but the genes that regulate skin repair have only partially been identified. Many experimental and clinical studies have demonstrated varied, but in most cases beneficial, effects of exogenous growth factors on the healing process. However, the roles played by endogenous growth factors have remained largely unclear. Initial approaches at addressing this question focused on the expression analysis of various growth factors, cytokines, and their receptors in different wound models, with first functional data being obtained by applying neutralizing antibodies to wounds. During the past few years, the availability of genetically modified mice has allowed elucidation of the function of various genes in the healing process, and these studies have shed light onto the role of growth factors, cytokines, and their downstream effectors in wound repair. This review summarizes the results of expression studies that have been performed in rodents, pigs, and humans to localize growth factors and their receptors in skin wounds. Most importantly, we also report on genetic studies addressing the functions of endogenous growth factors in the wound repair process.Keywords
This publication has 101 references indexed in Scilit:
- The EGFR family and its ligands in human cancerEuropean Journal Of Cancer, 2001
- Coordinate expression of NGF and α-smooth muscle actin mRNA and protein in cutaneous wound tissue of developing and adult ratsCell and tissue research, 2000
- Regulatory Role of Endogenous Interleukin-10 in Cutaneous Inflammatory Response of Murine Wound HealingBiochemical and Biophysical Research Communications, 1999
- Cloning of mouse FGF10 and up-regulation of its gene expression during wound healing.Gene, 1997
- Basic fibroblast growth factor mediates angiogenic activity in early surgical woundsSurgery, 1996
- Strong Induction of Activin Expression after Injury Suggests an Important Role of Activin in Wound RepairDevelopmental Biology, 1996
- The expression of transforming growth factor type beta in fetal and adult rabbit skin woundsJournal of Pediatric Surgery, 1994
- Quantitation of cytokine levels in skin graft donor site wound fluidBurns, 1993
- Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory diseaseNature, 1992
- Human wound fluid from acute wounds stimulates fibroblast and endothelial cell growthJournal of the American Academy of Dermatology, 1991