Light‐Promoted Nickel Catalysis: Etherification of Aryl Electrophiles with Alcohols Catalyzed by a NiII‐Aryl Complex
- 12 April 2020
- journal article
- research article
- Published by Wiley in Angewandte Chemie-International Edition
- Vol. 59 (31), 12714-12719
- https://doi.org/10.1002/anie.202003359
Abstract
A highly effective C‐O coupling reaction of (hetero)aryl electrophiles with primary and secondary alcohols is reported. Catalyzed by a Ni(II)‐aryl complex under long‐wave UV (390‐395 nm) irradiation in the presence of a soluble amine base without any additional photosensitizer, the reaction allows for the etherification of aryl bromides, aryl chlorides as well as sulfonates with a wide range of primary and secondary aliphatic alcohols, affording synthetically important ethers. The intramolecular C‐O coupling is also possible. The catalysis appears to proceed via a Ni(I)‐Ni(III) cycle.Funding Information
- National Natural Science Foundation of China (21871171)
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