Myocardial contractile function during ischemia and hypoxia.
- 1 February 1987
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation Research
- Vol. 60 (2), 153-168
- https://doi.org/10.1161/01.res.60.2.153
Abstract
There is good evidence that elevated [Ca2+]i, produced by an influx of Ca2+ in exchange for Na+, is the underlying pathology in reperfusion or reoxygenation damage. Further measurements of [Na+]i and [Ca2+]i during ischemia and reperfusion, coupled with information about metabolic levels, are needed to confirm or refute this hypothesis. Contributions to cell damage by other mechanisms, e.g., oxygen free radicals, certainly cannot yet be excluded.Keywords
This publication has 90 references indexed in Scilit:
- Sarcoplasmic reticulum contains adenine nucleotide-activated calcium channelsNature, 1985
- Measurement of cytosolic calcium with aequorin in dispersed rat ventricular cellsJournal of Molecular and Cellular Cardiology, 1985
- Free energy change of ATP-hydrolysis: a causal factor of early hypoxic failure of the myocardium?,Journal of Molecular and Cellular Cardiology, 1982
- Modulation of tension generation at the myofibrillar level—an analysis of the effect of magnesium adenosine triphosphate, magnesium, pH, sarcomere length and state of phosphorylationBasic Research in Cardiology, 1980
- Decoupling of heart muscle cells: Correlation with increased cytoplasmic calcium activity and with changes of nexus ultrastructureThe Journal of Membrane Biology, 1980
- Muscular fatigue investigated by phosphorus nuclear magnetic resonanceNature, 1978
- Mechanism of early “pump” failure of the ischemic heart: Possible role of adenosine triphosphate depletion and inorganic phosphate accumulationThe American Journal of Cardiology, 1977
- Reperfusion of the ischemic myocardiumJournal of Molecular and Cellular Cardiology, 1977
- The influence of metabolic inhibitors upon the transmembrane slow inward current in the mammalian ventricular myocardiumNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1975
- Positive and Negative Inotropic Effects of Elevated Extracellular Potassium Level on Mammalian Ventricular MuscleThe Journal of general physiology, 1972