Inactivation of the Mismatch Repair System in Pseudomonas aeruginosa Attenuates Virulence but Favors Persistence of Oropharyngeal Colonization in Cystic Fibrosis Mice
- 1 May 2007
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 189 (9), 3665-3668
- https://doi.org/10.1128/jb.00120-07
Abstract
The inactivation of the mismatch repair (MMR) system of Pseudomonas aeruginosa modestly reduced in vitro fitness, attenuated virulence in murine models of acute systemic and respiratory infections, and decreased the initial oropharyngeal colonization potential. In contrast, the inactivation of the MMR system favored long-term persistence of oropharyngeal colonization in cystic fibrosis mice. These results may help in understanding the reasons for the low and high prevalences, respectively, of hypermutable P. aeruginosa strains in acute and chronic infections.Keywords
This publication has 28 references indexed in Scilit:
- Stage‐Specific Adaptation of HypermutablePseudomonas aeruginosaIsolates during Chronic Pulmonary Infection in Patients with Cystic FibrosisThe Journal of Infectious Diseases, 2007
- Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patientsProceedings of the National Academy of Sciences of the United States of America, 2006
- Efficacy and Potential for Resistance Selection of Antipseudomonal Treatments in a Mouse Model of Lung Infection by HypermutablePseudomonas aeruginosaAntimicrobial Agents and Chemotherapy, 2006
- Hypermutation Is a Key Factor in Development of Multiple-Antimicrobial Resistance inPseudomonas aeruginosaStrains Causing Chronic Lung InfectionsAntimicrobial Agents and Chemotherapy, 2005
- Mutator phenotype confers advantage inEscherichia colichronic urinary tract infection pathogenesisFEMS Immunology & Medical Microbiology, 2005
- Novel Mouse Model of ChronicPseudomonas aeruginosaLung Infection Mimicking Cystic FibrosisInfection and Immunity, 2005
- Experimental Adaptation of Salmonella typhimurium to MiceGenetics, 2004
- Lack of Association between Hypermutation and Antibiotic Resistance Development inPseudomonas aeruginosaIsolates from Intensive Care Unit PatientsAntimicrobial Agents and Chemotherapy, 2004
- Costs and Benefits of High Mutation Rates: Adaptive Evolution of Bacteria in the Mouse GutScience, 2001
- Small-Colony Variants of Pseudomonas aeruginosa in Cystic FibrosisClinical Infectious Diseases, 1999